- Title
- Reply
- Creator
- Brown, Simon G. A.; Stone, Shelley F.; Fatovich, Daniel M.; Isbister, Geoffrey K.
- Relation
- Journal of Allergy and Clinical Immunology Vol. 132, Issue 6, p. 1457-1457
- Publisher Link
- http://dx.doi.org/10.1016/j.jaci.2013.09.013
- Publisher
- Mosby
- Resource Type
- journal article
- Date
- 2013
- Description
- Vadas and Liss have restated their previous finding that severe anaphylaxis is associated with low activity of the enzyme that deactivates the platelet-activating factor (PAF), PAF-acetylhydrolase (PAF-AH). They conclude that low PAF-AH activity should be used to identify at-risk individuals for targeted interventions. This assumes that low PAF-AH activity will identify those most likely to benefit. However, most people experiencing severe anaphylaxis do not have low PAF-AH activity, yet may equally benefit from the same interventions. Another assumption is that low PAF-AH activity is a driver of severity rather than a consequence of it. Both Vadas et al and our group used samples collected during anaphylaxis, which may alter PAF-AH activity through oxidative stress or consumption/deactivation of the enzyme by the PAF. It is possible that PAF-AH activity might then return to normal in many cases. Bansal et al highlighted this potential problem and found no difference in PAF-AH activity between 40 controls and 59 people who had previously experienced severe anaphylaxis.
- Subject
- anaphylaxis; platelet-activating factor; acetylhydrolase
- Identifier
- http://hdl.handle.net/1959.13/1045940
- Identifier
- uon:14547
- Identifier
- ISSN:0091-6749
- Language
- eng
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